Bridging the divide between pathogenesis and detection in lymphedema
Identifieur interne : 002C91 ( Main/Exploration ); précédent : 002C90; suivant : 002C92Bridging the divide between pathogenesis and detection in lymphedema
Auteurs : J. Brandon Dixon [États-Unis] ; Michael J. Weiler [États-Unis]Source :
- Seminars in cell & developmental biology [ 1084-9521 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Lymphoedème, Vaisseaux lymphatiques.
- diagnostic : Lymphoedème.
- physiopathologie : Lymphoedème.
- étiologie : Lymphoedème.
- Angiographie par résonance magnétique, Animaux, Fluorescence, Humains, Rayons infrarouges, Tumeurs.
English descriptors
- KwdEn :
- MESH :
- complications : Neoplasms.
- diagnosis : Lymphedema.
- etiology : Lymphedema.
- pathology : Lymphatic Vessels, Lymphedema.
- physiopathology : Lymphedema.
- Animals, Fluorescence, Humans, Infrared Rays, Magnetic Resonance Angiography.
Abstract
While our understanding of the lymphatic system has improved substantially in the past few decades, the translation of this knowledge into improved healthcare solutions for patients suffering from secondary lymphedema has been severely limited. The challenge facing clinicians is two-fold. First, there is no reliable, affordable, diagnostic capable of detecting the disease before symptoms of the lymphedema develop and the efficacy of treatment options becomes limited. Second, our understanding of the disease pathogenesis, its risk factors, and the underlying physiologic mechanisms is still in its infancy. These two challenges go hand in hand as limited diagnostic options have hindered our ability to understand lymphedema progression, and the lack of known underlying mechanisms involved in the disease prohibits the development of new diagnostic targets. This review serves to discuss the recent developments in clinical and lab research settings of both lymphedema diagnostic technologies and our understanding of the mechanisms driving disease risk and progression. We will show how these two lines of research are synergistically working with the ultimate goal of improving patient outcomes for those suffering from this horrible disease, identifying key areas of further research that are warranted to move the field forward and provide clinical relief for this neglected patient population.
Url:
DOI: 10.1016/j.semcdb.2014.12.003
PubMed: 25545813
PubMed Central: 4418628
Affiliations:
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Le document en format XML
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Brandon" last="Dixon">J. Brandon Dixon</name><affiliation wicri:level="4"><nlm:aff id="A1">George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Atlanta</settlement><region type="state">Géorgie (États-Unis)</region></placeName><orgName type="university">Georgia Institute of Technology</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Atlanta</settlement><region type="state">Géorgie (États-Unis)</region></placeName><orgName type="university">Georgia Institute of Technology</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Atlanta</settlement><region type="state">Géorgie (États-Unis)</region></placeName><orgName type="university">Georgia Institute of Technology</orgName></affiliation></author><author><name sortKey="Weiler, Michael J" sort="Weiler, Michael J" uniqKey="Weiler M" first="Michael J." last="Weiler">Michael J. Weiler</name><affiliation wicri:level="4"><nlm:aff id="A3">Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Atlanta</settlement><region type="state">Géorgie (États-Unis)</region></placeName><orgName type="university">Georgia Institute of Technology</orgName></affiliation></author></analytic><series><title level="j">Seminars in cell & developmental biology</title><idno type="ISSN">1084-9521</idno><idno type="eISSN">1096-3634</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Fluorescence</term><term>Humans</term><term>Infrared Rays</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (diagnosis)</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Lymphedema (physiopathology)</term><term>Magnetic Resonance Angiography</term><term>Neoplasms (complications)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Angiographie par résonance magnétique</term><term>Animaux</term><term>Fluorescence</term><term>Humains</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (diagnostic)</term><term>Lymphoedème (physiopathologie)</term><term>Lymphoedème (étiologie)</term><term>Rayons infrarouges</term><term>Tumeurs ()</term><term>Vaisseaux lymphatiques (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Fluorescence</term><term>Humans</term><term>Infrared Rays</term><term>Magnetic Resonance Angiography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Angiographie par résonance magnétique</term><term>Animaux</term><term>Fluorescence</term><term>Humains</term><term>Rayons infrarouges</term><term>Tumeurs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">While our understanding of the lymphatic system has improved substantially in the past few decades, the translation of this knowledge into improved healthcare solutions for patients suffering from secondary lymphedema has been severely limited. The challenge facing clinicians is two-fold. First, there is no reliable, affordable, diagnostic capable of detecting the disease before symptoms of the lymphedema develop and the efficacy of treatment options becomes limited. Second, our understanding of the disease pathogenesis, its risk factors, and the underlying physiologic mechanisms is still in its infancy. These two challenges go hand in hand as limited diagnostic options have hindered our ability to understand lymphedema progression, and the lack of known underlying mechanisms involved in the disease prohibits the development of new diagnostic targets. This review serves to discuss the recent developments in clinical and lab research settings of both lymphedema diagnostic technologies and our understanding of the mechanisms driving disease risk and progression. We will show how these two lines of research are synergistically working with the ultimate goal of improving patient outcomes for those suffering from this horrible disease, identifying key areas of further research that are warranted to move the field forward and provide clinical relief for this neglected patient population.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region><settlement><li>Atlanta</li></settlement><orgName><li>Georgia Institute of Technology</li></orgName></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name></region><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><name sortKey="Weiler, Michael J" sort="Weiler, Michael J" uniqKey="Weiler M" first="Michael J." last="Weiler">Michael J. Weiler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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